Which of the following agents decrease systemic vascular resistance?

The correct choice highlights that both Sevoflurane and Desflurane are agents known for their ability to decrease systemic vascular resistance. These agents are inhalational anesthetics commonly used in clinical practice.

Sevoflurane provides a smooth induction and maintains hemodynamic stability, affecting vascular resistance in a way that can lead to vasodilation. Similarly, Desflurane is characterized by a rapid onset and offset of action, and it too has the effect of decreasing systemic vascular resistance through relaxation of vascular smooth muscle, facilitating vasodilation.

This combined action results in a decrease in systemic vascular resistance, which can be particularly advantageous in maintaining hemodynamic stability during surgical procedures.

Other agents in the options, such as Halothane, while having some anesthetic properties, also possess characteristics that can influence hemodynamic stability differently by potentially increasing systemic vascular resistance due to their effects on myocardial depressant properties and other factors. Therefore, Sevoflurane and Desflurane are more definitive in their action of decreasing systemic vascular resistance, making the selected answer accurate.